As Crash said...check the "Dreaded Rail Cap Failure" ref docs !
http://www.sonido-7.com/d8b/maintenance.html#Post8
The Dreaded Rail Cap Failure
This problem occurs on older d8bs and is accompanied by the following symptoms:
A loud thump from every output. Thump Thump Thump (somewhere around 80 BPM)
Lights and meters flashing on and off in double time to the thump
The lights on the pan pots twirl around
No control over the console from the GUI
GUI shows no signs of trouble
Sometimes audio will pass and sometimes not
Sometimes a restart will help but then it comes back
Eventually nothing will stop it
Note: Some d8bs will have similar symptoms if there is an interruption to clock or if an incoming clock is present when the d8b is booted up or if any digital device connected to the digital cards is on when the d8b is booted up. For instance, some boards will act up every time a MOTU 2408 is connected to the DIO8 card when booting. In these cases the thump does not always occur (though sometimes it does), and the pan pot lights don't twirl around, but there will be flashing lights and meters, and the monitor may (but not always) show "DSP Error, Last State Unknown" or similar.
If you have these symptoms and are not an expert audio maintenance technician, you need the help of an authorized Mackie Service Center.